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KMID : 0358319970380030306
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Korean Journal of Urology
1997 Volume.38 No. 3 p.306 ~ p.311
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Intracavernosal Self-Injection Therapy for the Patients with Erectile Dysfunction: Comparison of Erectile Response and Complications between Bimix and Trimix Solution
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Abstract
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Purpose:
@EN To compare the efficacy of Bimix solution (27.3mg/ml papaverine and 0.9 mg/ml phentolamine) versus Trimix solution (18.8% mg/ml papaverine, 0.6 mg/ml phentolamine and 6.3㎍/ml prostaglndin E1) in terms of erectile response and complications.
@ES Materials and Methods:
@EN We comparatively analyzed the erectile response and the incidence of pain, prolonged erection (>4 hours), and corporal fibrosis of either medication in the 155 impotent patients who used Bimix solution for intracavernous pharmacotherapy (mean
duration: 15 months) and thereafter used Trimix solution (mean 12 months).
@ES Results:
@EN Erectile response to Trimix solution was significantly better than Bimix solution (p<0.01). The mean dose of Bimix solution was higher than Trimix solution (0.43 ml. vs. 0.34ml, p<0.05). The severe pain enough for impediment to intercourse
occured
in 6.5% of the Trimix group, while no patients of the Bimix group experienced (p<0.01). The corporal fibrosis was noted in 8.4% of the Trimix group and 16.1% of the Bimix group. However, there was no significant difference between the two group
(p=0.08). The incidence of prolonged erection was significantly lower (p<0.05) in the Trimix group (2.6%) than in the Bimix group (12.3%). A total of 139 patients(89.7%) finally selected Trimix solution
@ES Conclusions:
@EN The Trimix solution was more effective and safer than Bimix solution for the treatment of erectile dysfunction.
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KEYWORD
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